COVID19-040– April 22,  2020
 

Dear Patients,

 
 

Every day there is a panoply of scary information; some of it may be disinformation, some of it may be news reporting intended to tease you into reading the article, some of it may even be true. The virus is mutating, you can get the virus again, hydroxychloroquine increases the chances for a bad outcome, this fall and winter will be worse than now, and it goes on and on. It seems like as soon as we get a break, then the cycle of negative news slaps us in the face again and again. You may find this article helpful about Headline Stress Disorder. The bottom line is "many people will experience some level of distress in relation to their news consumption." For some, the more they consume, the worse they feel. So, you might find that setting news time and source limits may be helpful, as well as being careful with social media.

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Ultimately, you cannot beat finding a way to be less reactive to stress. Work on being imperturbable. It takes practice and it is something I work on all the time. Do not dwell on the past, learn from it; do not worry about the future, plan for it. Be present minded; the present can be a perfect moment. I love this quote from Lester Levenson. I've read much of his work; he's the guru of imperturbability.

The numbers:

  • Maryland: 14,775 cases 631 deaths 4.3% fatality rate (up)

  • (deaths are +47, down from +68 yesterday)

Let me give you a trend to follow that is based on the Ro, referred to as the R naught value (thank you AT). Ro is a disease's basic reproductive number and it represents how an infectious disease spreads through a population. The idea is that in order for a disease to spread, a sick person must be able to get at least one other person sick. If a disease spreads to fewer than one other person, on average, the outbreak can't happen. Click this link - it shows how each state is doing; Maryland is presently at 1.05 We want this value to be <1.0 and lower is better. To receive our 'get out of jail' card, it needs to be sustained for 14 days.

Diagnostics and Therapeutics: 

  • Continued conflicting data on the use of hydroxychloroquine, alone or in combination with azithromycin - it has not clearly been shown to be beneficial based on a recently released VA study. In fact, those who were given hydoxychloroquine may have done worse. My interpretation of this is that the population that it has been given to may be sicker and therefore their poor outcome. These drugs may still have a role if used early in high-risk patients who have not deteriorated. Time will tell.

  • In the LA study, done by USC, it was estimated that approximately 4.1% of the county's adult population has antibody to COVID-19. This is consistent with the Santa Clara study. This translates to 220,000 - 440,000 adults in the US have been infected. This is 28-55 times higher than the confirmed number of cases reported in the US at the time of the study in early April. This is good news; it means the prevalence is high, there is a large number of asymptomatic patients and the fatality rate may be significantly lower.

  • NY began its antibody prevalence study yesterday. They will randomly select 3,000 New Yorkers at 20 grocery stores around the state. A finger-stick blood sample will be obtained and tested for antibodies. I'm hopeful to see those numbers soon.

On a musical note:

In honor of Earth Day 2020 - What a Wonderful World

earth day graphic

And on a lighter note with today being the 50th anniversary of Earth Day

 
 

Harry A. Oken, M.D.

Office: 410-910-7500, Fax: 410-910-2310
Cell: 443-324-0823
 
Adjunct Professor of Medicine
University of Maryland School of Medicine
 
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